Duncan received scheduled commercial airline flights between 1954 and 1973. Central Airlines began service in 1954 using Douglas DC-3s on flights to Dallas and Fort Worth, as well as to Oklahoma City, with a stop in Lawton.
In 1967 Central merged into the original Frontier Airlines, which used Convair 580 aircraft on its flights until ending service in 1972. Mid-Continent Airlines, a small commuter airline at the time, provided flights to Dallas, Oklahoma City, and Altus, Oklahoma for a time in 1973.